Common cnidium extract application in fatty liver

Today, we are told that common cnidium assists the body in producing nitric oxide, which relaxes smooth muscles and works to encourage healthy sexual function, and it has been used to treat male sexual dysfunction. It also shows promise in the areas of osteoporosis, allergies and carcinoma research. it is also said to be 'anti-aging' and to 'build up strength', highly vague claims.

Common cnidium

Common cnidium extract application in fatty liver:

Osthole in common cnidium extract is able to reduce fatty liver induced by Alcohol; in a study where mice were fed 52% of caloric intake as ethanol for 4 weeks and then given 10-40mg/kg Osthole for 6 weeks, Osthole was able to normalize alterations in CPT1A and CYP2E1 transcription rates (made abnormal with prolonged alcohol ingestion, and conducive to further fat buildup) and was able to decrease liver fat content in a rehabilitative manner.These effects are also seen when the same dose of osthole is co-ingested, and are attributed to anti-oxidant and anti-inflammatory mechansims, although Osthole does appear to induce PPARa activation which can then reduce DGAT and HMG-CoA activity; a shift towards lipid mobilization rather than storage. Minor dose-dependence is seen, with more Osthole exerting more protection but 10mg/kg seeming to be the most cost-effective dose.

Although there are no current definitive warnings listed with the use of Cnidium Monnier Herbal Supplement, it is not advisable for pregnant or nursing women to use this herb unless under the care of a physician.

Concerning oral supplements, practitioners recommend a standard dose between six and 15 grams. For skin treatments, where cnidium is found in creams or ointments, the dose is irrelevant.

Relevant plant extract:
hops extract
artichoke extract